Peptides and Peptidomimetics as Tools to Probe Protein-Protein Interactions – Disruption of HIV-1 gp41 Fusion Core and Fusion Inhibitor Design
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منابع مشابه
Identification of a Human Protein-Derived HIV-1 Fusion Inhibitor Targeting the gp41 Fusion Core Structure
The HIV-1 envelope glycoprotein (Env) gp41 plays a crucial role in the viral fusion process. The peptides derived from the C-terminal heptad repeat (CHR) of gp41 are potent HIV fusion inhibitors. However, the activity of these anti-HIV-1 peptides in vivo may be attenuated by their induction of anti-gp41 antibodies. Thus, it is essential to identify antiviral peptides or proteins with low, or no...
متن کاملCrystal structure of the simian immunodeficiency virus (SIV) gp41 core: conserved helical interactions underlie the broad inhibitory activity of gp41 peptides.
The gp41 subunit of the envelope protein complex from human and simian immunodeficiency viruses (HIV and SIV) mediates membrane fusion during viral entry. The crystal structure of the HIV-1 gp41 ectodomain core in its proposed fusion-active state is a six-helix bundle. Here we have reconstituted the core of the SIV gp41 ectodomain with two synthetic peptides called SIV N36 and SIV C34, which fo...
متن کاملHelical interactions in the HIV-1 gp41 core reveal structural basis for the inhibitory activity of gp41 peptides.
The HIV-1 gp41 envelope protein mediates membrane fusion that leads to virus entry into the cell. The core structure of fusion-active gp41 is a six-helix bundle in which an N-terminal three-stranded coiled coil is surrounded by a sheath of antiparallel C-terminal helices. A conserved glutamine (Gln 652) buried in this helical interface replaced by leucine increases HIV-1 infectivity. To define ...
متن کاملHIV Entry and Its Inhibition Minireview
envelope complexreadily undergoes receptor-activated The human immunodeficiency virus type 1 (HIV-1) is conformational change suggests that its native state is an enveloped virus, and its envelope protein complex metastable, again similar to the pH-activated envelope controls the key process of viral entry. This envelope protein of influenza virus (Carr et al., 1997). That is, protein determine...
متن کاملHIV Entry and Its Inhibition
envelope complexreadily undergoes receptor-activated The human immunodeficiency virus type 1 (HIV-1) is conformational change suggests that its native state is an enveloped virus, and its envelope protein complex metastable, again similar to the pH-activated envelope controls the key process of viral entry. This envelope protein of influenza virus (Carr et al., 1997). That is, protein determine...
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تاریخ انتشار 2017